The Colombian finished less than a minute behind Chris Froome (Team Sky) during last year's edition of the race and the American-registered squad will look to change tack in the hope of finding stage wins for the remainder of the race.
In the week building up to the race, Cannondale was one of several bike manufacturers to launch new aero framesets and for the opening stage in Noirmoutier-en-l'Île, the entire EF Education First-Drapac team raced aboard the new Cannondale SystemSix, which has been tested extensively in races since March of this year.
The final version of the bike is finished in the fluoro pink and green team colours of EF-Drapac and is paired with a full Shimano Dura-Ace R9170 groupset.
Components specialists Vision provides the team with wheels and finishing kit, with Uran opting for a Vision Metron 5D integrated carbon cockpit.
As with several of the recently released framesets from other manufacturers, Cannondale has produced a direct-mount rear derailleur hanger for the Shimano Dura-Ace R9150 rear derailleur. In an eye-catching and colour-coordinated pink finish, the component also doubles up as a chain catcher to prevent any throwing of the chain off the cassette.
EF Education First-Drapac is one of several WorldTour and Tour de France teams to run 25mm Vittoria Corsa tyres.
For stage nine of the race on the cobbles to Roubaix, EF Education First-Drapac switched from SystemSix framesets to the endurance-focused Synapse framesets, before switching to the lightweight SuperSix framesets as the race hit the Alps.
Click or swipe through the gallery above for a closer look at Rigoberto Uran's Cannondale SystemSix.
Cannondale SystemSix full specification
Frameset: Cannondale SystemSix
Front brake: Shimano Dura-Ace R9120
Rear brake: Shimano Dura-Ace R9120
Brake/shift levers: Shimano Dura-Ace R9170
Front derailleur: Shimano Dura-Ace R9150
Rear derailleur: Shimano Dura-Ace R9150 with custom hanger for Cannondale SystemSix
Cassette: Shimano Dura-Ace R9100, 11-30
Crankset: Cannondale SISL, 53/39 FSA chainrings
Wheelset: Vision Metron 55 SL tubular
Tyres: Vittoria Corsa, 25mm tubular
Handlebars/stem: Vision Metron 5D integrated, 400mm wide, 110mm stem
Tape/grips: Prologo
Pedals: Shimano Dura-Ace R9100
Saddle: Prologo Scratch 2
Seat post: Cannondale SystemSix
Bottle cages: Tacx Ciro
Critical measurements
Rider height: 1.73m
Saddle height from bottom bracket (centre to top): 700mm